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Pyrisept为季铵盐类外用药物,它与洗必大(Hibitane)均为应用较广的消毒剂,用于皮肤、伤口的消毒和膀胱及尿道的洗涤。两药抗菌作用机制也甚类似,都被菌体胞浆膜上的阳电荷吸附,致使膜的半透性破坏,细菌体内容物凝结而达到杀菌的目的。然而两药的杀菌效力都有很大差别。作者将Pyrisept和洗必太按1/2、1/4、1/8、1/16、1/32倍数稀释,用体外方法对某些从泌尿道感染分离
Pyrisept, a quaternary ammonium salt topical drug, is a widely used disinfectant with Hibitane for skin and wound disinfection and bladder and urinary tract cleaning. The antibacterial mechanism of the two drugs is also very similar. Both are adsorbed by the positive charges on the bacterial cytoplasmic membrane, resulting in the semi-permeable destruction of the membrane and the condensation of bacterial contents to achieve the purpose of sterilization. However, the bactericidal efficacy of the two drugs are very different. The authors diluted Pyrisept and chlorhexidine at 1/2, 1/4, 1/8, 1/16, 1/32 multiples and isolated them from urinary tract infections in vitro