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研究目的探讨胸腹水α_1-抗胰蛋白酶在单纯肝硬化腹水与恶性肿瘤胸腹水中的鉴别价值.方法采集恶性肿瘤患者的胸水或腹水及单纯肝硬化患者的腹水,用速率散射比浊法检测α_1-抗胰蛋白酶水平,测定结果进行t检验.结果37例恶性肿瘤胸腹水α_1-抗胰蛋白酶测定值为0.90~4.60/dl,30例单纯肝硬化腹水α_1-抗胰蛋白酶测定值为0.45~2.20mg/d,(P<0.001)。α_1-抗胰蛋白酶含量1.01mp/dl作为鉴别单纯肝硬化腹水与恶性肿瘤胸腹水的界值,其敏感性为93.94%,特异性为92.5%,阳性预示值为93.94%,阴性预示值为92.59%。结论恶性肿瘤胸腹水α_1-抗胰蛋白酶含量明显高于单纯肝硬化腹水,并可作为诊断恶性肿瘤胸腹水的一个指标.
Objective To investigate the value of thoracic and ascitic fluid α_1-antitrypsin in the differential diagnosis of cirrhotic ascites and malignancy in abdominal ascites. Methods: Collect ascites from pleural fluid or ascites and cirrhosis in patients with malignant tumors. - Antitrypsin levels were measured and t-tests were performed. The results showed that the values of α_1-antitrypsin in malignant tumors of ascites were 0.90 to 4.60/dl, and those of 30 cases of ascites in liver cirrhosis were 0.45 to 2.20. Mg/d, (P<0.001). The α_1-antitrypsin content of 1.01 mp/dl was used as the cutoff value for distinguishing ascites from simple cirrhosis and malignancy. The sensitivity was 93.94%, the specificity was 92.5%, the positive predictive value was 93.94%, and the negative predictive value was 92.59. %. Conclusion The content of α_1-antitrypsin in malignant pleural effusion and ascites is obviously higher than that in simple cirrhotic ascites, and it can be used as an indicator for the diagnosis of malignant pleural effusion and ascites.