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目的探讨t(8;21)急性髓系白血病(acute myeloid leukemia,AML)的临床特点及预后,提高对t(8;21)AML的认识。方法 2010年5月收治1例t(8;21)AML患者,对其临床资料并复习相关文献进行分析。患者因乏力、皮下瘀斑入院,查体发现患者有胸骨压痛,脾肋下3cm触及,血常规:白细胞80.37×109/L,异常细胞23%,取患者骨髓液行形态学、流式细胞术检测及染色体核型检测。结果患者诊断为急性粒细胞白血病部分分化型(AML-M2b),AML1/ETO融合基因阳性,染色体核型分析t(8;21)(q22;q22)。结论 t(8;21)AML是一类较为特殊的急性髓系白血病,在诊断时需寻找疾病的预后因素并进行分层,实施个体化治疗。
Objective To investigate the clinical features and prognosis of t (8; 21) acute myeloid leukemia (AML) and to improve the understanding of t (8; 21) AML. Methods One case of t (8; 21) AML patients were admitted to our hospital in May 2010, and their clinical data and review related literature were analyzed. Patients due to fatigue, subcutaneous ecchymosis admitted to hospital, examination showed that patients with sternal tenderness, 3cm spleen ribs touch, blood: white blood cells 80.37 × 109 / L, 23% of abnormal cells, take patients with bone marrow fluid morphology, flow cytometry Detection and detection of chromosome karyotype. Results The patients were diagnosed as AML-M2b, AML1 / ETO fusion gene positive, chromosome karyotype analysis t (8; 21) (q22; q22). Conclusions t (8; 21) AML is a special type of acute myeloid leukemia. It needs to find out the prognostic factors of the disease and stratify it to carry out individualized treatment.