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目的:探讨podoplanin在直肠癌组织中的表达及其在淋巴结转移的关系。方法:应用免疫组化法检测110例直肠癌组织中podoplanin的表达水平和微淋巴管密度(LMVD),并以90例良性病变直肠组织为对照。结果:podoplanin在直肠癌中的表达阳性率明显高于良性直肠组织(P<0.01)。podoplanin阳性LMVD在Ⅲ～Ⅳ期明显高于Ⅰ～Ⅱ期(P<0.01);有淋巴结转移者的LMVD明显高于无淋巴结转移者(P<0.01)。podoplanin的表达与直肠癌患者的年龄、性别、肿瘤分化程度无关。结论:podoplanin在直肠癌淋巴管生成中起着重要的作用,可作为直肠癌诊断和判断预后的免疫组织化学标志物。
Objective: To investigate the expression of podoplanin in rectal cancer and its relationship with lymph node metastasis. Methods: The expression of podoplanin and lymphatic vessel density (LMVD) in 110 cases of rectal cancer were detected by immunohistochemistry and 90 cases of benign lesion were used as control. Results: The positive rate of podoplanin in rectal cancer was significantly higher than that in benign rectal tissues (P <0.01). The positive expression of podoplanin in stage Ⅲ ~ Ⅳ was significantly higher than that in stage Ⅰ ~ Ⅱ (P <0.01). The LMVD of patients with lymph node metastasis was significantly higher than those without lymph node metastasis (P <0.01). The expression of podoplanin was not related to the age, sex and tumor differentiation degree of patients with rectal cancer. Conclusion: podoplanin plays an important role in the lymphangiogenesis of rectal cancer and can be used as an immunohistochemical marker for the diagnosis and prognosis of rectal cancer.