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目的：探讨人乳头状瘤病毒（HPV）18型感染与人乳腺癌病因学之间的关系。方法：采用生物素标记的分子原位杂交技术检测柳州地区女性乳腺癌、导管内乳头状瘤和正常乳腺组织中HPV 18 DNA。结果：乳腺癌、导管内乳头状瘤和正常乳腺组织中HPV 18 DNA的阳性率分别为48．0％、30．0％和16．7％。多种组织学类型的乳腺癌组织中有HPV 18 DNA的存在且以整合型感染为主。癌组中淋巴结转移组HPV 18 DNA的阳性率显著高于无淋巴结转移组（P＜ 0．05）。结论本地区女性乳腺癌组织中有HPV18型感染的存在，HPV18型感染与乳腺癌的发生密切相关，HPV 18 DNA的阳性表达与乳腺癌的转移有关。
Objective: To investigate the relationship between human papillomavirus (HPV) 18 infection and etiology of human breast cancer. Methods: HPV18 DNA in female breast cancer, intraductal papilloma and normal breast tissue was detected by biotin-labeled molecular in situ hybridization. Results: The positive rates of HPV 18 DNA in breast cancer, intraductal papilloma and normal breast tissue were 48.0%, 30.0% and 16.7%, respectively. HPV 18 DNA is present in many histological types of breast cancer tissues and is predominantly an integrated infection. The positive rate of HPV 18 DNA in lymph node metastasis group was significantly higher than that in non-lymph node metastasis group (P <0.05). CONCLUSIONS: HPV18 infection exists in female breast cancer tissues in this region. HPV18 infection is closely related to the occurrence of breast cancer. The positive expression of HPV 18 DNA is associated with the metastasis of breast cancer.