【摘 要】
：
In human cells, the heterogeneous nuclear ribonucleoproteins (hnRNP) are represented by a group of polypeptides, with various molecular properties, comprizing t
【机 构】
：
Institute of Biochemistry,Institute Curie
论文部分内容阅读
In human cells, the heterogeneous nuclear ribonucleoproteins (hnRNP) are represented by a group of polypeptides, with various molecular properties, comprizing the most abundant constituents of the cell nucleus. Autoantibodies to hnRNPs have been reported in patients suffering from different rheumatic dieseases since 1980s. Experimental evidence indicates that hnRNP complexes undergo substantial structural changes during mRNA formation and export. However, how this contributes to disease development still has to be elucidated. Here some preliminary physicochemical features of RNA-protein folding and stability patterns of newly characterized hnRNP A3 with further functional implications in development of systemic human autoimmune states are reported.
其他文献
细度是羊毛最重要的经济性状之一,羊毛细度育种研究意义重大.由于羊毛细度早在毛囊发育过程中就已经决定,故首先应该对毛囊发育的机理有一定的了解,对控制细度的机制有一个总
采用UASB反应器处理1,4-丁二醇生产废水时,分别接种颗粒污泥、絮状污泥及两者的混合污泥,研究不同接种污泥对处理效果的影响。结果表明,接种颗粒污泥的反应器处理效果最好,但接种混合污泥时亦能取得较好的驯化及处理效果;接种颗粒污泥可以提高系统的最大COD容积负荷、抗污染负荷冲击能力及产气量,同时可降低挥发性脂肪酸的积累对微生物活性的抑制;在保持COD去除率>70%的条件下,3组反应器的最大COD容积
为明确甲基磺酸乙酯(EMS)对大豆品种诱变的后代变异情况,利用0.5%EMS溶液处理7个大豆品种的种子,对M2、M3代主要农艺性状的遗传变异进行分析比较。结果表明:各世代农艺性状均
以溶液培养的三角叶滨藜(Atriplex triangularis)为材料,测定分析了在PEG诱导的渗透胁迫条件下,适量的NaCl对其光合作用和水分吸收的影响,以探讨环境溶液中NaCl对植物适应干旱的影响。结果表明,PEG诱导的渗透胁迫导致三角叶滨藜植株吸水困难、叶绿素含量降低、光合系统受损、生长受抑制、生物量减少;而在PEG渗透胁迫的处理液中添加10-40mmol·L-1NaCl可以明显降低植株
考察了腐殖土反应器(HSR)的反应时间分别为12、24和48 h的3组侧流腐殖土SBR系统(HSR12-SBR1、HSR24-SBR2和HSR48-SBR3)的除磷效果。结果表明,3组系统对TP的去除率分别为(64.5±24.0)%、(85.6±9.8)%和(93.6±8.0)%,HSR48-SBR3的除磷效果明显高于HSR24-SBR2和HSR12-SBR1。通过荧光原位杂交技术(FISH)分析
采用一种新型的生物滤池,以制革废水的生化处理出水为研究对象,重点考察了新型滤池对COD和氨氮的去除效果。结果表明,采用两级串联生物滤池深度处理生化处理后的制革废水,当进水COD为300～500 mg/L、氨氮为150～350 mg/L时,出水COD<250 mg/L、氨氮<35mg/L,出水水质能够达到当地的制革行业污染物排放标准,但为确保COD和氨氮同时达到当地的排放要求,建议水力停留时间在24
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
千粒重是油菜重要的产量相关性状之一,构建油菜遗传连锁图谱是研究其产量性状基因的前提。本研究利用小孢子培养技术,选育出了甘蓝型油菜大粒品系(G-42)和小粒品系(7-9)的纯
We studied the difference in thermostability of photosystem Ⅱ (PSⅡ) and leaf lipid composition between a T-DNA insertion mutant rice (Oryza sativa L.) VG28 an
Chlorophyllase (EC 3.1.1.14) is involved in the first step of chlorophyll degradation. Isolation of chlorophyllase genes greatly facilitates characterization of