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目的研究诱生型一氧化氮合酶、增殖细胞核抗原在胃癌中的表达,并探讨其关系。方法用免疫组化方法对浅表性胃炎、不典型增生、胃癌中诱生型一氧化氮合酶(iNOS)和增殖细胞核抗原(PCNA)表达进行原位观察和检测,并比较其相互关系。结果iNOS和PCNA在浅表性胃炎、不典型增生、胃癌中的表达程度呈递增形式,统计比较有显著性差异,iNOS和PCNA表达呈正相关。结论iNOS表达与细胞增殖有关,在胃癌的发生、发展中起重要作用。
Objective To study the expression of inducible nitric oxide synthase and proliferating cell nuclear antigen in gastric cancer and to explore its relationship. Methods The expression of iNOS and proliferating cell nuclear antigen (PCNA) in superficial gastritis, atypical hyperplasia and gastric cancer were observed and detected by immunohistochemistry in situ and compared with each other. Results The expression of iNOS and PCNA in superficial gastritis, atypical hyperplasia and gastric cancer showed an increasing form. There was a significant difference between the two groups. The expression of iNOS and PCNA was positively correlated. Conclusion The expression of iNOS is related to cell proliferation and plays an important role in the occurrence and development of gastric cancer.