As an effective therapeutic modality,high-intensity focused ultrasound (HIFU) can destroy tumour tissues by thermocoagulation with less metastasis,but it is still limited by inaccurate non-invasive temperature monitoring and efficacy evaluation.A model of electrical impedance measurement during HIFU therapy was established using the temperatureimpedance relationship.Based on the simulations of acoustic pressure,temperature,and electrical conductivity,the impedance of the phantom was calculated and experimentally demonstrated for different values of acoustic power values and treatment time.We proved that the relative impedance variation (RIV) increases linearly with the increasing treatment time at a fixed acoustic power,and the relative impedance variation rate shows a linear relationship with the acoustic power.The RIV and treatment time required for HIFU treatment efficacy are inversely proportional to the acoustic power and the square of acoustic power,respectively.The favourable results suggest that RIV can be used as an efficient indicator for noninvasive temperature monitoring and efficacy evaluation and may provide new strategy for accurate dose control of HIFU therapy.