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目的 研究延胡索乙素 (dl THP)对大鼠实验性心肌缺血的保护作用。方法 观察dl THP对垂体后叶素 (pit)所致大鼠心电图急性缺血性改变的预防作用以及对异丙肾上腺素 (Iso)引起心肌损伤大鼠的保护作用。结果 dl THP对垂体后叶素所致心电图改变有明显预防作用。能对抗Iso所致ECG的ST段升高。显著抑制心肌组织中磷酸肌酸激酶 (CPK)、乳酸脱氢酶 (LDH)的释放 ,降低血清CPK和LDH水平 ,保护心肌组织超氧化物歧化酶 (SOD)活性 ,减少丙二醛 (MDA)生成。结论 dl THP对实验性心肌缺血有明显的保护作用
Objective To study the protective effect of tetrahydropalmatine (dl THP) on experimental myocardial ischemia in rats. Methods The preventive effect of dl THP on the acute ischemic changes of rat electrocardiogram induced by pituitrin (pit) and the protective effect of isoproterenol (Iso) on myocardial injury in rats were observed. Results dl THP had a significant preventive effect on the electrocardiographic changes induced by pituitrin. ST-segment elevation can be counteracted by Iso-induced ECG. Significantly inhibit the release of phosphocreatine kinase (CPK) and lactate dehydrogenase (LDH) in cardiac muscle tissue, reduce serum CPK and LDH levels, protect myocardial tissue from superoxide dismutase (SOD) activity, and reduce malondialdehyde (MDA) generate. Conclusion dl THP has obvious protective effect on experimental myocardial ischemia