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目的研究苄索氯铵乳膏的抑菌作用和皮肤刺激性。方法采用稀释法和动物实验法,对苄索氯铵乳膏进行抑菌效果与皮肤刺激性评价。结果苄索氯铵乳膏10%稀释液对金黄色葡萄球菌和大肠杆菌作用2 min,抑菌率均为100%。多次涂抹完整皮肤刺激试验中,每天每只动物平均积分值为0.29。结论该苄索氯铵乳膏10%稀释液对两种试验菌具有良好的抑菌效果,对实验动物完整皮肤无刺激性。
Objective To study the bacteriostasis and skin irritation of benzethonium chloride cream. Methods The antibacterial effect and skin irritation of benzethonium chloride cream were evaluated by dilution method and animal experiment. Results Benzethonium chloride cream 10% dilution on Staphylococcus aureus and Escherichia coli for 2 min, the inhibition rate was 100%. In the multiple application complete skin irritation test, the average integration value per animal per day was 0.29. Conclusion The benzethonium chloride cream 10% dilution has good bacteriostatic effect on the two kinds of test bacteria, and has no irritation on the intact skin of experimental animals.