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目的 研究丙烯腈对小鼠睾丸组织某些标志酶活性的影响 ,探讨丙烯腈对雄性小鼠生殖损伤的机制及早期敏感指标。方法 用分光光度法检测睾丸组织匀浆中葡萄糖 6 磷酸脱氢酶 (G 6 PD)、乳酸脱氢酶同工酶 (LDHx)、β 葡糖苷酸酶 (β G)及酸性磷酸酶 (ACP)的活性。 结果 G 6 PD、LDHx、β G及ACP各指标与对照组比较未见显著性差异 (P >0 0 5 )。结论 在本实验染毒时间和染毒剂量范围内 ,丙烯腈对小鼠睾丸组织中酶活性 (G 6 PD、LDHx、β G及ACP)未见影响。
Objective To study the effect of acrylonitrile on the activity of some markers of testis in mice and to explore the mechanism and early sensitive indices of acrylonitrile on reproductive injury in male mice. Methods The levels of glucose 6-phosphate dehydrogenase (LDHx), β-glucuronidase (GG) and acid phosphatase (ACP) in testis tissue were detected by spectrophotometry. Activity. Results There was no significant difference in G 6 PD, LDHx, β G and ACP between the two groups (P> 0.05). Conclusions Acrylonitrile had no effect on the enzyme activity (G 6 PD, LDHx, β G and ACP) in the testis tissue of mice in the exposure time and exposure dose range.