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本研究分别观察了ＮＯ_２染毒和ＬＰＧ燃烧产物自然暴露对Ｗｉｓｔａｒ雄性成年大鼠肺脂质过氧化、肺胶原含量和尿ＨＯＰ排泄的影响及其相互关系。结果发现７．５２ｍｇ／ｍ~３的ＮＯ_２对三者均有一定影响，染毒剂量不同大鼠尿ＨＯＰ排泄也有相应的变化。尿ＨＯＰ的变化早于肺胶原含量，且两者有一定的相关关系。ＬＰＧ燃烧产物暴露期间，尿ＨＯＰ含量一直高于对照组，但未见肺胶原含量的变化。８周时尿ＨＯＰ与肺脂质过氧化物之间有显著的正相关关系。结果表明尿ＨＯＰ可以比较灵敏地反映ＮＯ_２和ＬＰＧ燃烧产物对肺的损伤及对肺胶原代谢的影响。
In this study, we observed the effects of NO 2 and natural exposure to LPG combustion on lung lipid peroxidation, lung collagen content and urinary HOP excretion in male Wistar rats and their correlation. The results showed that 7.52mg / m ~ 3 of NO_2 have certain impact on the three, different doses of rat urine HOP excretion also has a corresponding change. Urinary HOP changes earlier than lung collagen content, and the two have a certain correlation. Urine HOP levels were consistently higher in the LPG combustion products than in the control group, but no change in lung collagen content was observed. There was a significant positive correlation between urinary HOP and pulmonary lipid peroxidation at 8 weeks. The results showed that urinary HOP could reflect lung injury and lung collagen metabolism of NO 2 and LPG combustion products more sensitively.