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大鼠马杉氏肾炎也称为肾毒性血清性肾炎(NSGN),其发病早期肾小球合成的白三烯(LT)升高,伴有肾小球增殖性核抗原(PCNA)(+)细胞及肾小球增殖活性(GPA)的增加。用花生四烯酸5-脂氧化酶抑制剂治疗NSGN大鼠,可抑制肾小球LTB4的合成及PCNA(+)细胞、GPA的升高。用X线照射去除外周血白细胞也可抑制PCNA(+)细胞及GPA的升高。已知在NSGN中肾小球合成的LT来源于浸润的白细胞[1],本研究证实肾小球白细胞衍生的LT促进NSGN的肾小球细胞增殖。
Rat also known as nephrotoxic serum nephritis (NSGN), the incidence of glomerular synthesis of leukotrienes (LT) increased, accompanied by glomerular proliferative nuclear antigen (PCNA) (+) Increased cell and glomerular proliferative activity (GPA). Treatment of NSGN rats with arachidonic acid 5-lipoxygenase inhibitor can inhibit the synthesis of glomerular LTB4 and the increase of PCNA (+) cells and GPA. X-ray irradiation to remove peripheral white blood cells can also inhibit the PCNA (+) cells and GPA increased. It is known that glomerular synthesis of LT in NSGN originates from infiltrating leukocytes [1] and this study demonstrates that glomerular leukocyte-derived LT promotes glomerular cell proliferation of NSGNs.