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目的 评价心肌肌钙蛋白Ⅰ (cardiactroponinⅠ ,cTnI)对危重新生儿心肌损伤的诊断价值。方法 用化学发光免疫法及免疫抑制法分别测定 30例健康儿 (足月儿 1 4例 ,早产儿 1 6例 )及 66例危重儿血清中cTnI与CK -MB水平。并作心电图与超声心动图检查。结果 cTnI正常值范围为 0～ 1 93ng/mL。无心肌损伤危重儿均 <2ng/mL ,而 >2ng/mL心肌损伤率 1 0 0 % ,明显高于CK -MB升高者 46 1 5 % ,P <0 0 5。结论 cTnI对危重新生儿心肌损伤有高度特异性 ,明显增高者示预后不良。
Objective To evaluate the diagnostic value of cardiac troponin Ⅰ (cTnI) in myocardial damage in critically ill neonates. Methods The levels of cTnI and CK-MB in serum of 30 healthy children (14 full-term infants, 16 premature infants) and 66 critically ill children were determined by chemiluminescence immunoassay and immunosuppression. And for ECG and echocardiography. Results cTnI normal range of 0 ~ 1 93ng / mL. The children without critical myocardial injury were less than 2ng / mL in critically ill children, while those with> 2ng / mL of myocardial injury were 100% more likely to be hypertrophy than those with elevated CK-MB (46.1%, P <0.05). Conclusions cTnI is highly specific for myocardial damage in critically ill neonates. A significantly higher cTnI indicates a poor prognosis.