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The effect of Pb2+ on 3H-DL-Glutamate (3H-DL-Glu) binding in the membrane preparations from the hippocampus of rat brain was investigated with a view to explaining the cognitive and learning deficits produced by the heavy metal. The results indicated that Pb2+ (3. 1-25. 0 μmol.L -1 ) inhibited 3 H-DL-Glu binding in a concentration-dependent manner . Scatchard analysis further revealed that at a concentration of 6. 3 μmol.L-1 Pb2 + interfered with binding mainly through significantly decreasing the density of binding sites. This finding provided an important insight into Pb2+ -induced impairments in learning and memory previously documented in children and in experimental animals chronically exposed to Pb~(2+)
The effect of Pb2 + on 3H-DL-Glutamate (3H-DL-Glu) binding in the membrane preparations from the hippocampus of rat brain was investigated with a view to explaining the cognitive and learning deficits produced by the heavy metal. The results indicated that Pb2 + (3. 1-25. 0 μmol.L -1) inhibited 3 H-DL-Glu binding in a concentration-dependent manner. Scatchard analysis further revealed that at a concentration of 6. 3 μmol.L-1 Pb2 + interfered This finding provided an important insight into Pb2 + -induced impairments in learning and memory previously documented in children and in experimental animals chronically exposed to Pb ~ (2+)