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目的:观察舒血宁联合小剂量低分子肝素治疗高FIB(纤维蛋白原)急性脑梗死的临床疗效。方法:将符合标准的120例急性脑梗死患者随机分为两组,双盲给药。治疗组:0.9%氯化钠注射液250m l+舒血宁针20m l静脉点滴,每天一次,持续10天;同时用低分子肝素钙针4100u腹部皮下注射,每天两次,持续10天;对照组:低分子右旋糖酐注射液500m l静脉点滴,每天一次,持续10天。治疗前后进行CSS、B I评分及FIB测定并比较两组间是否存在差异。结果:治疗前两组间CSS评分无差异无统计学意义(p>0.05),治疗后d14、d28、d90两组间评分差异有统计学意义(p<0.05),治疗组均低于对照组;治疗后d28及d90的B I,治疗组优于对照组(p<0.05)。治疗前两组间血浆FIB含量差异无统计学意义(p>0.05),治疗后d3、d7、d14治疗组血浆FIB含量下降明显,低于对照组(p<0.05);治疗后90d总有效率治疗组优于对照组(X2=7.743,p<0.05)。结论:舒血宁联合低分子肝素治疗对伴有血浆FIB含量增高的急性脑梗死患者具有良好的临床疗效,有利于伴有血浆FIB含量增高的急性脑梗死患者神经功能缺损的康复。
Objective: To observe the clinical efficacy of Shuxuening combined with low-dose low molecular weight heparin in the treatment of acute FIB (fibrinogen) acute cerebral infarction. Methods: A total of 120 patients with acute cerebral infarction who met the criteria were randomly divided into two groups, double-blind. Treatment group: 0.9% sodium chloride injection 250m l + Shuxuening needle 20m l intravenously once a day for 10 days; while using low molecular weight heparin calcium needle 4100u abdominal subcutaneous injection twice a day for 10 days; control group : Low molecular weight dextran injection 500ml intravenous drip once a day for 10 days. Before and after treatment, CSS, B I score and FIB were measured and compared between the two groups for differences. Results: There was no significant difference in CSS score between the two groups before treatment (p> 0.05). There was significant difference between the two groups on d14, d28 and d90 after treatment (p <0.05), and the treatment group were lower than the control group ; After treatment d28 and d90 BI, the treatment group than the control group (p <0.05). There was no significant difference in plasma FIB levels between the two groups before treatment (p> 0.05). The plasma FIB levels of d3, d7 and d14 treatment groups decreased significantly after treatment (p <0.05), and the total effective rate 90 days after treatment The treatment group was better than the control group (X2 = 7.743, p <0.05). Conclusion: Shuxuening combined with LMWH has a good clinical curative effect in patients with acute cerebral infarction accompanied by increased plasma FIB levels, which is beneficial to the rehabilitation of neurological deficits in patients with acute cerebral infarction accompanied by increased plasma FIB levels.