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目的观察中药复脾汤对STZ大鼠胰腺的影响,探讨从脾胃论治消渴病的机理。方法采用链脲佐菌素(STZ)腹腔注射制备糖尿病大鼠模型,将大鼠分为正常对照组、糖尿病模型组、西药美吡达对照组、正常给药组、预防给药组。观察各组大鼠的胰岛素和胰腺病理等指标的变化情况。结果在修复胰腺损伤及升高胰岛素上,复脾汤明显好于其他各组,预防组疗效更好(P<0.05,P<0.01)。结论复脾汤对实验性大鼠有胰腺保护作用。
Objective To observe the effect of Fufang Decoction on the pancreas of STZ rats and to explore the mechanism of treating diabetes thirst by spleen and stomach. Methods Diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ). The rats were divided into normal control group, diabetic model group, methystatin control group, normal group and preventive group. The changes of insulin and pancreatic pathology in each group were observed. Results In the repair of pancreatic injury and insulin, Fufang Tang was significantly better than the other groups, and the preventive effect was better (P <0.05, P <0.01). Conclusion Fufang decoction has protective effects on experimental rats.