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抗髓过氧化物酶（抗ＭＰＯ）抗体是抗中性粒细胞浆抗体（ＡＮＣＡ）中的一种，其对结节性多动脉炎（ＰＡＮ）的诊断价值日益受到重视。我们应用ＥＬＩＳＡ方法对１９例ＰＡＮ患者血清进行检测，６／１９例抗体阳性（３２％），其中５例临床表现合并肺、肾损害，１例合并皮肤、肾脏病变；另外６例中的１例动态监测，当病变处于急性活动期时，抗ＭＰＯ抗体阳性；而病变趋于慢性化及临床症状趋于缓解时，抗ＭＰＯ抗体阴性。此外，对２２例正常对照及２２例其它肾脏病患者进行检测，抗ＭＰＯ抗体均无一例阳性。因而提示抗ＭＰＯ抗体为ＰＡＮ特别对于合并肺、肾损害的ｐＡＮ的敏感指标；抗ＭＰＯ抗体出现与疾病的活动性有关，可作为疾病活动性的指标
Anti-myeloperoxidase (MPO) antibodies are one of the anti-neutrophil plasma antibodies (ANCA) and their diagnostic value for polyangiitis nodosum (PAN) is gaining more and more attention. Serum samples from 19 patients with PAN were detected by ELISA. 6 of 19 patients (32%) had positive serum antibody, of which 5 had clinical manifestations of lung and kidney damage, 1 had skin and kidney lesions, and 1 of 6 Dynamic monitoring showed that anti-MPO antibody was positive when the lesions were in acute phase, and anti-MPO antibody was negative when the lesions tended to be chronic and the clinical symptoms tended to be alleviated. In addition, 22 cases of normal controls and 22 cases of other nephrotic patients were tested, no anti-MPO antibodies were positive. Therefore, the anti-MPO antibody is a sensitive indicator of PAN especially for pAN with lung and kidney damage. Anti-MPO antibody is associated with the activity of the disease and can be used as an indicator of disease activity