目的　研究硒氟联合作用对小鼠学习记忆行为的影响及其脑内机理。方法　采用饮水加氟、加硒的方法。结果　与对照组相比 ,较高浓度氟能使小鼠学习能力呈显著损伤 ,并能引起脑内SOD活性显著下降 (P <0 0 5 ) ,适当浓度的硒与氟联合作用 ,则可拮抗氟的这种作用 ,而高浓度与氟则产生协同毒性作用。结论　一定浓度的硒对小鼠氟致学习能力的损伤可能有改善作用 ,并且这种改善作用可能和硒提高其脑内SOD活性有关 Objective To study the effects of selenium and fluorine on learning and memory in mice and its intracerebral mechanism. Methods drinking water plus fluoride, plus selenium method. Results Compared with the control group, higher concentrations of fluoride caused significant damage to learning ability of mice and decreased the activity of SOD in the brain (P <0.05). When the appropriate concentrations of selenium and fluoride were combined, they could be antagonized This effect of fluorine, while the high concentration of fluorine and synergistic toxic effects. Conclusion Selenium at a certain concentration may impair the learning ability of fluoride induced by fluoride in mice, and this effect may be related to selenium increasing SOD activity in brain