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目的 探讨 2型糖尿病 (2 -DM)合并冠心病 (CHD)患者的胰岛素抵抗 (IR)及与肿瘤坏死因子 -α(TNF -α)、内皮素(ET)的关系。方法 分别采用氧化酶法、放免法测定 3 0例健康人及 47例 2 -DM、2 1例 2 -DM合并CHD患者的空腹血糖 (FBG)、血清胰岛素 (FINS)、ET、TNF -α ,计算胰岛素敏感性指数 (ISI)。结果 两组 2 -DM患者均存在高胰岛素血症 (HRI)及ISI下降 ;两组患者血浆ET、血清TNF -α均高于对照组 ,且血浆ET、TNF -α与胰岛素呈正相关 ;血浆ET、血清TNF -α与ISI呈负相关。结论 2 -DM患者及合并CHD患者均存在IR ,IR与血浆ET、血清TNF -α水平升高有关 ,二者相互影响、相互促进。
Objective To investigate the relationship between insulin resistance (IR), tumor necrosis factor-α (TNF-α) and endothelin (ET) in type 2 diabetes mellitus (2DM) patients with coronary heart disease (CHD) Methods The levels of fasting blood glucose (FBG), serum insulin (FINS), ET, TNF-α and TNF-α in 30 healthy people and 47 patients with 2-DM and 21 patients with 2-DM combined with CHD were determined by oxidase and radioimmunoassay Insulin sensitivity index (ISI) was calculated. Results Serum levels of plasma ET and serum TNF-α were significantly higher in both 2-DM patients than those in the control group. Plasma ET, TNF-α and plasma insulin levels were positively correlated with plasma ET , Serum TNF-α was negatively correlated with ISI. Conclusion Both IR patients with 2-DM and those with CHD have IR, which is related to the increase of plasma ET and serum TNF-α, and their mutual influence and mutual promotion.