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本文报道应用厌氧棒状杆菌菌苗(76-27株)治疗60例多种肿瘤转移的癌性胸水,其中56例未合并任何抗癌化疗,治疗后能使大量血性胸水迅速消退,未见复发。经治疗1～4次后胸水控制者占81.7％,有效率达96.7％,生存期有显著延长。实验检查发现经菌苗治疗后,胸水中大量癌细胞受到免疫效应的影响而很快消失。在动物实验中,电镜证明菌苗能明显地激活巨噬细胞,对瘤细胞发生直接接触抑制作用,胞质内线粒体凝集变性使瘤细胞崩解消失。
This article reports on the use of anaerobic coryneform bacterins (76-27 strain) to treat 60 cases of cancerous pleural effusions with multiple tumor metastases, of which 56 cases did not incorporate any anti-cancer chemotherapy. After treatment, a large number of bloody pleural effusions could quickly subside and no recurrence was found. . After 1-4 times of treatment, 81.7% of the pleural fluid was controlled, and the effective rate was 96.7%. The survival period was significantly prolonged. The experimental examination revealed that a large number of cancer cells in the pleural effusion were quickly lost after being treated with bacterin vaccine. In animal experiments, electron microscopy showed that the bacterins could activate macrophages obviously, and had direct contact inhibition on tumor cells. The mitochondrial aggregation in the cytoplasm caused the tumor cells to disintegrate and disappear.