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目的探讨脑少突胶质细胞瘤颅外转移的临床和病理学特点。方法对1例脑少突胶质细胞瘤颅外转移病例进行临床和病理组织学观察,并复习相关文献。结果原发性肿瘤的肿瘤细胞中等大小,均匀一致,细胞膜清楚,胞质肿胀、透亮,核圆、位于中央,典型的蜂窝状。转移后的肿瘤细胞呈多形性,部分区域瘤细胞呈上皮样,部分区域胞质透明并伴出血、坏死。免疫组化示肿瘤细胞vimentin、GFAP、MAP-2和nestin弥漫强(+),部分S-100和Syn(+),CK(AE1/AE3)、CD34、desmin、myoglobin和HMB45(+)。FISH技术证实肿瘤细胞有较高的1p/19q杂合性缺失率。结论脑少突胶质细胞瘤预后较好,很少发生颅外转移,随诊至今患者仍然存活。
Objective To investigate the clinical and pathological features of extracranial metastases of brain oligodendrogliomas. Methods One case of extracranial metastases of brain oligodendroglioma was observed clinically and histopathologically, and the related literatures were reviewed. Results The tumor cells of primary tumors were of the same size, uniform and clear cytoplasm, swollen cytoplasm, translucent and nuclear round, and were located in the central and typical honeycomb. Metastatic tumor cells were pleomorphic, part of the tumor cells were epithelial-like, part of the cytoplasm was transparent and with bleeding, necrosis. Immunohistochemistry showed that the tumor cells vimentin, GFAP, MAP-2 and nestin were diffuse (+), partially S-100 and Syn (+), CK (AE1 / AE3), CD34, desmin, myoglobin and HMB45 (+). FISH technique confirmed that the tumor cells have a high 1p / 19q loss of heterozygosity. Conclusions Brain oligodendroglioma has a good prognosis and few extracranial metastases. The patients are still alive after the procedure.