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目的观察尿毒症患者甲状旁腺素(PTH)对r-HuEPO疗效的影响。方法患者78例,根据Hb水平分为两组,A组为Hb<90 g/L(n=45),B组为Hb≥90 g/L(n=33),测定两组的PTH水平。观察r-HuEPO、1.25(OH)2D3治疗前后两组Hb、HCT、PTH变化。结果 A组PTH明显高于B组(P<0.01),r-HuEPO治疗3个月后两组Hb、HCT均有提高,A组上升幅度(P<0.05)低于B组(P<0.01);1.25(OH)2D3治疗后血PTH有所下降(P<0.05)。结论高PTH加重尿毒症贫血,降低r-HuEPO疗效。1.25(OH)2D3治疗可降低PTH水平。
Objective To investigate the effect of parathyroid hormone (PTH) on the efficacy of r-HuEPO in patients with uremia. Methods Totally 78 patients were divided into two groups according to the Hb level. The Hb level was 90 g / L (n = 45) in group A and the level of PTH in group B was 90 g / L (n = 33). The changes of Hb, HCT and PTH in two groups before and after treatment with r-HuEPO and 1.25 (OH) 2D3 were observed. Results The PTH in group A was significantly higher than that in group B (P <0.01). The levels of Hb and HCT in both groups increased after 3 months of treatment with r-HuEPO. The increase in group A was lower than that in group B (P <0.01) (P <0.05); PTH decreased after 1.25 (OH) 2D3 treatment. Conclusion High PTH aggravates uremia anemia and decreases the efficacy of r-HuEPO. 1.25 (OH) 2D3 treatment can reduce PTH levels.