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目的:观察强化阿托伐他汀治疗对急性冠脉综合征(ACS)患者血脂水平的短期影响。方法:收集100例ACS患者,入院当天(the day of admission,D0)、入院第一天(the first day,D1)及入院第二天(The Second Day,D2)分别给予阿托伐他汀80mg治疗,入院D0立即采血化验血脂参数包括总胆固醇(total cholesterol,TC)、低度脂蛋白(LDL-cholesterol,LDL-C)、高密度脂蛋白(HDL-cholesterol,HDL-C)、甘油三酯(triglycerides,TG),分别在D1和D2晨起空腹复查。结果:总胆固醇的平均基线水平为5.24±0.07(D0),低密度脂蛋白为3.26±0.07,高密度脂蛋白胆固醇为1.07±0.07,甘油三酯为1.31±0.07。口服阿托伐他汀80毫克后第一天早晨,TC水平下降6.1%(D1)(与D0相比P<0.001),第二日下降13.2%(D2)(与D0相比P<0.001),LDL-C下降5.8%(D1)(DO与D1相比,P<0.001)和15.6%(D2)(DO与D2相比,P<0.001);HDL-C下降7.5%(D1)(DO与D1相比,P<0.001)和12.1(D2)(DO与D2相比,P<0.001);相反TG水平升高20.6%(D1)(DO与D1相比,P<0.001)和25.5%(D2)(DO与D2相比,P<0.001)。结论:强化他汀治疗对ACS患者血脂短期的影响与长期的影响是不同的,TC,LDL和HDL在短期内是下降的,而TG是升高的。
Objective: To observe the short-term effects of intensive atorvastatin on blood lipids in patients with acute coronary syndrome (ACS). Methods: One hundred patients with ACS were enrolled. At the day of admission (D0), the first day of admission (D1) and the second day of admission (D2) were treated with atorvastatin 80 mg Blood samples were collected immediately after admission. Blood lipid parameters included total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-cholesterol), triglyceride triglycerides, TG), respectively, in D1 and D2 morning fasting review. RESULTS: The mean baseline cholesterol level was 5.24 ± 0.07 (D0), with low-density lipoprotein 3.26 ± 0.07, high-density lipoprotein cholesterol 1.07 ± 0.07, and triglycerides 1.31 ± 0.07. On the first morning after oral administration of atorvastatin 80 mg, the TC level decreased 6.1% (D1) (P <0.001 vs. D0) and 13.2% (D2) the next day (P <0.001 vs. D0) LDL-C decreased by 5.8% (D1) (DO and D1 compared to P <0.001) and 15.6% (D2) (DO and D2 compared to P <0.001) (P <0.001 compared with D1, P <0.001) and 12.1 (D2) (P <0.001 vs DO); in contrast, the TG level increased by 20.6% D2) (DO vs. D2, P <0.001). CONCLUSIONS: The effect of statin therapy on short-term plasma lipids in patients with ACS is different from the long-term effects, with TC, LDL, and HDL declining in the short term and TG being elevated.