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目的了解广州地区儿童腹泻中轮状病毒(RV)感染的情况,为临床诊断和治疗提供可靠实验数据。方法收集某院2010年1月至2012年12月住院和门诊的腹泻儿童粪便标本1 878,采用免疫层析双抗体夹心法进行A组轮状病毒(RV)抗原检测,并比较分析检测数据。结果 1 878例腹泻标本中[年龄范围在(1.99±2.37)岁],有616例RV结果阳性,阳性率为32.80%;其中0~1岁组腹泻患儿童阳性率可达36.21%(构成比69.48%),其次为1~2岁年龄组腹泻儿童占31.92%(构成比15.91%),2~3岁年龄组腹泻儿童占33.74%(构成比9.09%),可见0~3岁年龄段腹泻儿童(构成比共占94.48%)年龄段为高发期。以每年秋冬季节10、11、12和1月份(4个月构成比为82.46%)为发病高峰。结论轮状病毒是本地区儿童腹泻(0~14岁)的主要病原,0~3岁儿童是轮状病毒的易感人群,以秋冬季节10、11、12和1月份为流行高峰。
Objective To understand the status of rotavirus (RV) infection in children with diarrhea in Guangzhou and provide reliable experimental data for clinical diagnosis and treatment. Methods A total of 1878 children with diarrhea in hospital and outpatient department from January 2010 to December 2012 were enrolled in this study. Group A rotavirus (RV) antigen was detected by immunochromatographic double antibody sandwich method. The detection data were compared and analyzed. Results In 1 878 cases of diarrhea (age range: 1.99 ± 2.37 years), 616 cases were positive for RV and the positive rate was 32.80%. The positive rate of diarrhea children in 0-1 year old group was 36.21% 69.48%), followed by children aged 1-2 years with diarrhea accounted for 31.92% (constituent ratio 15.91%), children aged 2-3 years with diarrhea accounted for 33.74% (constituent ratio 9.09%), showing diarrhea in 0-3 years age group Children (constitute a total of 94.48% than the age group for the high incidence period. The autumn and winter seasons 10, 11, 12 and January (4 months constitute ratio of 82.46%) for the peak incidence. Conclusions Rotavirus is the main cause of diarrhea (0-14 years old) in children in this area. Children aged 0-3 years are susceptible to rotavirus. The prevalence is highest in autumn, winter, October, October, January and January.