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目的:探讨H型高血压患者血清同型半胱氨酸(Hcy)、尿酸(UA)及胱抑素C(Cyst-C)水平对颈动脉粥样硬化发生的预测价值。方法:本研究于2014年5月~2015年5月期间,选择我院收治确诊为H型高血压患者163例为研究对象,根据其颈动脉内膜中层厚度(c IMT)的不同分为c IMT正常组(51例)、c IMT增厚组(54例)和颈动脉斑块组(58例)。检测并比较三组间性别、年龄、血清Hcy、Cyst-C、UA、血糖(GLU)、血脂、血尿素氮(Bun)、血肌酐(Scr)水平,分析其与颈动脉c IMT的关系,并采用logistic回归分析颈动脉粥样硬化的影响因素。结果:三组间HDL-C、Hcy、Cyst-C、UA水平比较,差异均存在统计学意义(均P<0.05);c IMT与Hcy、Cyst-C、UA均呈现正相关关系(r=0.23,0.32,0.30;P<0.05),与HDL-C水平呈现负相关关系(r=-0.410,P<0.05);Logistic回归分析显示Hcy、Cyst-C、UA水平是颈动脉粥样硬化危险因素(OR=1.203,6.395,1.023;均P<0.05)。结论:H型高血压患者血清Hcy、Cyst-C及UA水平均与c IMT正相关,是导致颈动脉粥样硬化的独立危险因素,可用于临床早期预测动脉粥样硬化发生与发展。
Objective: To investigate the predictive value of serum homocysteine (Hcy), uric acid (UA) and Cyst-C in carotid atherosclerosis in patients with Hypertension. Methods: From May 2014 to May 2015, 163 cases of Hypertension diagnosed in our hospital from January 2014 to May 2015 were selected as the study subjects, and were divided into three groups according to the carotid intima-media thickness (c IMT) IMT normal group (51 cases), IMT thickening group (54 cases) and carotid plaque group (58 cases). The levels of serum Hcy, Cyst-C, UA, GLU, blood lipids, blood urea nitrogen (Bun) and serum creatinine (Scr) were detected and compared between the three groups. Logistic regression was used to analyze the influencing factors of carotid atherosclerosis. Results: There were significant differences in HDL-C, Hcy, Cyst-C and UA between the three groups (all P <0.05). There was a positive correlation between c IMT and Hcy, Cyst- (R = -0.410, P <0.05). Logistic regression analysis showed that the levels of Hcy, Cyst-C and UA were the risk of carotid atherosclerosis Factors (OR = 1.203, 6.395, 1.023; all P <0.05). Conclusions: Serum levels of Hcy, Cyst-C and UA in patients with Hypertension are positively correlated with c IMT, which are independent risk factors for carotid atherosclerosis. They can be used to predict the occurrence and development of atherosclerosis in the early stage of Hypertension.