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聚集诱导发光效应(AIE)在荧光传感、生物成像领域具有广阔的应用前景.近红外发射的荧光染料具有组织穿透性高、细胞低损伤,以及生物组织自荧光干扰小等优点.设计并合成了一种荧光增强型的AIE荧光体系DTPE-Tau;其具有近红外荧光发射特性,且细胞摄取能力强;并在炎症细胞中过度表达的酯酶的催化下,能有效清除细胞中过度表达的活性氧簇(ROS).此外,该荧光体系还具有许多优势,例如斯托克斯位移大、细胞毒性低和光稳定性好.DTPE-Tau被成功地应用于活细胞中追踪牛磺酸的释放和活性氧的清除.
AIE has broad application prospects in the field of fluorescence sensing and bioimaging.Fluorescent dyes with near infrared emission have the advantages of high tissue penetrability, low cell damage, and low self-fluorescence interference of biological tissues.Design and A fluorescence-enhanced AIE fluorescent system, DTPE-Tau, was synthesized. It has near-infrared fluorescence emission characteristics and high cellular uptake capacity. It catalyzes the overexpression of esterase in inflammatory cells and effectively eliminates overexpression in cells Reactive oxygen species (ROS) .In addition, the fluorescent system has many advantages such as large Stokes shift, low cytotoxicity and good light stability. DTPE-Tau has been successfully applied to the tracking of taurine in living cells Release and elimination of reactive oxygen species.