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目的观察奥曲肽持续静脉泵入辅助治疗恶性肠梗阻对患者血清C-反应蛋白(CRP)及D-二聚体(D-Dimer)水平的影响。方法将204例恶性肠梗阻患者随机分为试验组和对照组各102例,对照组患者仅采用基础治疗,试验组患者采用基础加奥曲肽持续静脉泵入治疗,测定2组患者CRP及D-Dimer水平,并评价治疗效果。结果试验组的总有效率70.6%显著高于对照组的22.5%;2组患者治疗2周后血清CRP水平和D-Dimer水平均较治疗前均有明显降低,且试验组均低于对照组,差异均有统计学意义(P<0.05)。结论奥曲肽持续静脉泵入可明显降低恶性肠梗阻患者血清CRP及D-Dimer的水平,疗效显著,值得在临床中研究和应用。
Objective To observe the effect of continuous intravenous injection of octreotide on patients with malignant intestinal obstruction on C-reactive protein (CRP) and D-dimer (D-dimer) levels. Methods Totally 204 patients with malignant intestinal obstruction were randomly divided into experimental group and control group, 102 cases in each group. The control group received only basic treatment. The patients in the experimental group were treated with continuous intravenous injection of octreotide, and the CRP and D-Dimer Level, and evaluate the treatment effect. Results The total effective rate in experimental group was 70.6%, which was significantly higher than that in control group (22.5%). Serum CRP level and D-Dimer level in two groups were significantly lower than those before treatment , The differences were statistically significant (P <0.05). Conclusion Continuous intravenous injection of octreotide can significantly reduce the serum levels of CRP and D-Dimer in patients with malignant intestinal obstruction. The curative effect is significant and worth to be studied and applied in clinical practice.