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目的研究PXK基因多态性与汉族人系统性红斑狼疮(SLE)易感性的相关性。方法利用Illumina 610-Quad芯片对590例SLE患者和1135例正常对照样本进行基因分型,选取PXK基因的单核苷酸多态性(SNP)分型数据,用Plink1.03软件进行统计分析。结果PXK基因上7个SNPs(rs6445975、rs7622074、rs6786088、rs12637163、rs9817356、rs11710823和rs6767291)的等位基因频率在病例组和对照组间差异无统计学意义(P>0.05)。结论PXK基因多态性可能与汉族人SLE易感性不相关。
Objective To investigate the association between PXK polymorphism and susceptibility to SLE in Han Chinese. Methods 590 patients with SLE and 1135 normal controls were genotyped by Illumina 610-Quad chip. Single nucleotide polymorphism (SNP) typing data of PXK gene were selected and analyzed by Plink 1.03 software. Results There was no significant difference in allele frequency between the 7 cases (P> 0.05) and the control group for the 7 SNPs in the PXK gene (rs6445975, rs7622074, rs6786088, rs12637163, rs9817356, rs11710823 and rs6767291). Conclusion PXK polymorphism may not be related to susceptibility to SLE in Han Chinese.