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他汀类药物可减少围手术期心肌损伤、弥漫性心肌坏死、心肌梗死和无复流现象发生,可能与其降低炎症反应、改善内皮功能、抑制血栓形成等多效性作用有关。此外,强化他汀治疗可减少经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后发生对比剂肾病(contrast-induced nephropathy,CIN)的风险,可能是全因死亡率及心血管死亡率减低的非心源性机制。目前PCI术前强化他汀治疗成为临床医生关注的热点,本文将对PCI术前强化他汀的获益、作用机制以及安全性的相关研究新进展做一综述。
Statins can reduce perioperative myocardial injury, diffuse myocardial necrosis, myocardial infarction and no reflow phenomena, which may be related to its pleiotropic effect of reducing inflammation, improving endothelial function and inhibiting thrombosis. In addition, statin therapy reduces the risk of developing contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI), which may be due to a reduction in all-cause and cardiovascular mortality Cardiac mechanism. Currently, statin therapy before PCI is becoming a hot issue for clinicians. This article reviews the progress of the research on the benefits, mechanism and safety of statin before PCI.