根据致癌基因理论,细胞癌变首先需要细胞癌基因(c-onc)的激活,尔后被激活的c-onc或肿瘤病毒癌基因(v-onc)的表达产物参与一系列干扰和破坏正常代谢的活动。如果搞清各种致癌基因表达产物的功能及其在细胞癌变过程中所起的作用,癌变原理也就可见端倪了。因此,有关这方面的研究已开始成为致癌基因研究领域中一个新的前沿阵地。在癌基因的表达产物中,过去人们了解较多的是象pp60这类具有使酪氨酸磷酸化特性的表达产物。目前已经鉴定的癌基因产物虽然为数不多(表1);但在内 According to the theory of oncogenes, cell carcinogenesis first requires the activation of the oncogene c-onc, and subsequently the activated c-onc or v-onc expression product participates in a series of activities that disrupt and disrupt normal metabolism . If you figure out the function of various oncogene expression products and its role in the process of cancerization of cells, the principle of carcinogenesis can be seen. Therefore, research in this area has begun to become a new frontier in the field of oncogene research. Among the expression products of oncogenes, the expression products that have tyrosine phosphorylation properties such as pp60 have been known in the past. At present, although a few oncogene products have been identified (Table 1), they are included