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目的:分析上海临港地区孕妇孕期碘营养状态与孕妇及新生儿甲状腺功能的关系，为是否需要开展孕妇尿碘监测及采取补碘措施提供依据。方法:2017年10月至2018年10月，采用前瞻性随机抽样调查方法，选择在上海健康医学院附属第六人民医院东院产科门诊建卡产检的妊娠妇女作为调查对象，所有调查对象分为孕早（5~12周）、中（22~24周）、晚期（36~37周），采集24 h尿液和血样，测定尿碘含量、血清促甲状腺激素（TSH）、血清游离甲状腺素（FTn 4）、血清游离三碘甲状腺原氨酸（FTn 3）、甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TgAb）。在孕晚期孕妇的新生儿出生72 h后，采集足跟血测定新生儿TSH。分析不同孕期、不同尿碘水平孕妇甲状腺功能指标的差异，以及不同尿碘水平孕妇的新生儿TSH水平。n 结果:共调查孕早、中、晚期孕妇109、90、54例，孕早、中、晚期尿碘中位数分别为120.95、136.30、116.80 μg/L，不同孕期妇女尿碘含量比较差异无统计学意义（n P > 0.05），孕早、中、晚期尿碘 0.05). The proportions of urinary iodine level less than 150 μg/L in early, middle and late pregnancy were 75.2% (82/109), 61.1% (55/90) and 59.3% (32/54), respectively. The median values of serum TSH in early, middle and late pregnancy were 1.81, 1.95 and 2.29 mU/L, mean values of FT n 3 were (5.21 ± 0.84), (4.79 ± 0.72) and (4.13 ± 0.56)pmol/L, and means of FTn 4 were (16.48 ± 2.58), (15.02 ± 2.78) and (13.31 ± 1.87) pmol/L, respectively. The FTn 3 and FTn 4 levels in the late pregnancy were lower than those in the early and middle pregnancy, while the TSH levels in the late pregnancy were higher than those in the early and middle pregnancy. There were no significant difference in serum FTn 3, FTn 4 and TSH levels among early, middle and late pregnancy under different urinary iodine levels. The median TSH of newborn heel blood was 1.48 mU/L. There was no statistically significant difference between the neonatal heel blood TSH level of pregnant women with urinary iodine 0.05].n Conclusions:There is mild iodine deficiency in pregnant women in Lingang of Shanghai. However, due to the compensatory regulation, it has no significant effect on the thyroid function of mother and newborn. Monitoring of iodine nutrition of pregnant women should be carried out and iodine supplementation should be done scientifically and reasonably.