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用荧光分光光度法测定了不同孕期的275例被动吸烟孕妇和130例正常妊娠妇女血中儿茶酚胺(CA)含量,并对其与低出生体重儿(LBW)发生率之间的关系进行了探讨。结果表明:被动吸烟A组(平均每日被动吸烟5~14支)和B组(平均每日≥15支)孕妇孕中期和孕早期血中去甲肾上腺素(NE)含量,均显著高于同孕期正常妊娠组(P<0.05),且B组孕中期含量升高尤为显著(P<0.01);多巴胺(DA)含量与正常妊娠组比,仅B组临产前含量显著降低(P<0.05);被动吸烟A、8两组LBW发生率分别是正常妊娠组的2.27倍和3.21倍,其中小于胎龄儿(SGA)的发生率分别是正常妊娠组的2.91和3.50倍。提示被动吸烟所致孕妇血中NE明显升高与LBW的发生可能有关系。因此,社会和家庭对孕妇被动吸烟可能给胎儿发育所带来的危害应给予足够的重视。
The levels of catecholamine (CA) in 275 pregnant women and 130 pregnant women at different stages of pregnancy were determined by fluorescence spectrophotometry, and the relationship between them and the incidence of LBW was also discussed. The results showed that the levels of norepinephrine (NE) in pregnant women in passive smoking group A (average daily passive smoking 5 ~ 14) and group B (average daily ≥ 15) pregnant women were significantly higher than Compared with the normal pregnancy group (P <0.05), the content of the second trimester in group B was especially significant (P <0.01). Compared with normal pregnancy group, the content of dopamine in group B was significantly lower (P <0.05). The incidences of LBW in passive smoking group A and B were 2.27 and 3.21 times higher than those in normal pregnancy group respectively, and the incidences of SGA in passive smoking group were normal pregnancy group 2.91 and 3.50 times more. Tip passive smoking induced maternal serum NE significantly increased the occurrence of LBW may be related. Therefore, society and family should give enough attention to the harm that pregnant women may have caused by fetal passive smoking.