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[目的]检测重症肝病患者凝血因子的4项指标,探讨其临床意义。[方法]使用全自动血凝分析仪对某院237例重症肝病患者以及50例健康人进行凝血酶时间(TT)、活化部分凝血酶时间(APTT)、凝血酶原时间(PT)以及纤维蛋白原(FIB)的含量进行检测。[结果]重症肝病患者组与对照组相比凝血酶时间(TT)、活化部分凝血酶时间(APTT)、凝血酶原时间(PT)均明显延长,纤维蛋白原(FIB)的含量也显著减少,差异有统计学意义(P﹤0.01)。[结论]对重症肝病患者进行凝血因子检测可以较早发现患者的凝血机制障碍,可以预先发现重症肝病患者是否具有出血倾向,对预防和治疗出血、抢救以及预后治疗具有十分重要的临床意义。
[Objective] To detect four indexes of clotting factor in patients with severe liver disease and discuss its clinical significance. [Methods] Thrombin time (TT), activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrin were measured in 237 patients with severe liver disease and 50 healthy people in a hospital using automatic hemagglutination analyzer. The original (FIB) content was tested. [Results] Compared with the control group, the patients with severe liver disease had significantly longer thrombin time (TT), activated partial thromboplastin time (APTT) and prothrombin time (PT), and fibrinogen (FIB) , The difference was statistically significant (P <0.01). [Conclusion] The clotting factor test in patients with severe liver disease can detect the clotting mechanism obstacle of the patients earlier. It can find out whether the patients with severe liver disease have bleeding tendency in advance, which is of great clinical significance in the prevention and treatment of bleeding, rescue and prognosis.