论文部分内容阅读
目的探讨川芎嗪对大鼠脑损伤后行为学影响及其可能机制。方法将80只大鼠随机分为正常组、假手术组、损伤组及治疗组,每组20只。损伤组和治疗组大鼠采用改良Feeney法制作脑损伤动物模型,治疗组于脑损伤后给予川芎嗪治疗(120 mg/kg,1次/d),损伤组给予等量生理盐水腹腔注射。实验第14天比较不同组大鼠原位细胞凋亡情况和水迷宫试验结果。结果治疗组大鼠原位细胞凋亡阳性细胞数为(5.86±0.94),低于损伤组的(8.07±1.02),差异有统计学意义(P<0.05)。治疗组大鼠水迷宫试验中第1次穿过平台时间为(7.68±1.09)s,低于损伤组的(10.15±2.35)s;在靶象限活动时间为(86.14±16.68)s,高于损伤组的(62.38±19.67)s;穿过平台次数为(6.4±2.3)次,亦高于损伤组的(3.8±1.6)次,以上差异均有统计学意义(P<0.05)。结论川芎嗪可改善大鼠脑损伤后神经元凋亡和行为学变化。
Objective To investigate the effect of ligustrazine on the behavior and its possible mechanism after brain injury in rats. Methods 80 rats were randomly divided into normal group, sham operation group, injury group and treatment group, 20 rats in each group. Rats in the injury group and the treatment group were treated by modified Feeney method. The rats in the treatment group were treated with ligustrazine (120 mg / kg, once a day) after brain injury. The rats in the injury group were injected intraperitoneally with the same amount of saline. On the 14th day of experiment, the apoptosis of in situ cells in different groups was compared with the water maze test. Results The number of apoptotic cells in the untreated group was (5.86 ± 0.94), which was lower than that in the injured group (8.07 ± 1.02), the difference was statistically significant (P <0.05). In the water maze test, rats in the treatment group for the first time passed through the platform for (7.68 ± 1.09) s, which was lower than that for the injured group (10.15 ± 2.35) s; and the time spent in the target quadrant was (86.14 ± 16.68) s, (62.38 ± 19.67) s in the injury group, (6.4 ± 2.3) times in the platform, and (3.8 ± 1.6) times in the injury group. The above differences were statistically significant (P <0.05). Conclusion Tetramethylpyrazine can improve neuronal apoptosis and change of behavior after traumatic brain injury in rats.