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目的总结大豆异黄酮对绝经后妇女骨质疏松的疗效。方法在PubMed(1966-2007),Cochrane对照临床试验注册中心(Cochrane Library,Issue 3,2007),CINAHL(1982-2007)和CNKI(1970-2007)进行文章查询。结果总共发现了168篇文章,其中12篇文章为RCT。有3篇文章报道大豆异黄酮可以改善绝经后妇女的骨密度。5篇文章发现骨密度无改变。结论因为各研究中大豆的补充和持续时间都不相同,大豆异黄酮对绝经后妇女骨质疏松的疗效还需要进一步探索。
Objective To summarize the efficacy of soy isoflavones on postmenopausal women with osteoporosis. Methods The article was searched in PubMed (1966-2007), Cochrane Library, Issue 3, 2007, CINAHL (1982-2007) and CNKI (1970-2007). A total of 168 articles were found, of which 12 were RCTs. Three articles reported that soy isoflavones can improve bone mineral density in postmenopausal women. 5 articles found no change in bone mineral density. Conclusion Because soy supplementation and duration vary in each study, the efficacy of soy isoflavones on osteoporosis in postmenopausal women needs further exploration.