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急性鼻窦炎乃常见病,其发生与窦口阻塞(解剖变异和/或粘膜异常)后窦腔内氧张力降低、出现渗液、构成相对缺氧环境、有利于细菌繁殖等有关。呼吸道的粘纤系统是重要的防御机制,正常清除功能的障碍会促成炎症的发生。患急性鼻窦炎常分离到肺炎链球菌、流感嗜血杆菌和绿脓杆菌,这类细菌感染时的许多生化产物(如纤毛毒素、类脂寡糖、白细胞酶等)都能降低纤毛活力,使纤毛摆动频率(CBF)降低,从而抑制窦粘膜的清除功能,促成细菌感染。因兔上颌窦大,对感染的反应类似人类,故选用无感染的新西兰大白兔20只,分为4组,每组5只,氯胺酮麻醉下,剃毛消毒后,在面
Acute sinusitis is a common disease, its occurrence and sinus ostial obstruction (anatomical variation and / or mucosal abnormalities) after the sinus cavity oxygen tension decreased, there exudate, constitute a relatively hypoxic environment conducive to bacterial reproduction and so on. Visceral viscose fiber system is an important defense mechanism, the normal removal of obstacles to function will lead to the occurrence of inflammation. Acute sinusitis often isolated from Streptococcus pneumoniae, Haemophilus influenzae and Pseudomonas aeruginosa, such bacterial infections when many biochemical products (such as ciliary toxins, lipooligosaccharides, leukocyte enzymes, etc.) can reduce the cilia vitality, so that Ciliary Wobble frequency (CBF) decreased, thereby inhibiting the removal of sinus mucosal function, contributing to bacterial infection. Rabbit maxillary sinus, the response to infection similar to humans, so the selection of non-infected New Zealand white rabbits 20, divided into 4 groups of 5, ketamine anesthesia, shaving disinfection, the surface