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目的测定多囊卵巢综合征(PCOS)及2型糖尿病(T2DM)患者的血清Apelin水平,探讨其与肥胖、性激素、代谢指标及胰岛素抵抗的相关性。方法 24例PCOS患者、26例T2DM和22例正常糖调节(NGR)者按体重指数(BMI)≥25kg/m2或<25kg/m2又各自分为超重(over weight,OW)与正常体重(normal weight,NW)亚组,采用放射免疫法检测空腹血清Apelin水平,空腹血糖(FPG)、空腹胰岛素(FINS)、性激素水平,计算BMI,并以稳态模型方法计算胰岛素抵抗指数(HOMA-IR)。结果 PCOS组患者血清Apelin水平高于NGR组[(247.8±47.5)ng/Lvs.(220.2±42.3)ng/L,P<0.05],T2DM组患者血清Apelin水平明显高于NGR组[(249.5±55.2)ng/Lvs.(220.2±42.3)ng/L,P<0.05],血清Apelin水平在PCOS组及T2DM组间比较,差异无统计学意义。在PCOS组、T2DM及NGR组中,OW亚组Apelin水平高于相应NW亚组。空腹血清Apelin水平与BMI、FPG、FINS、HOMA-IR、TG及TC呈正相关(r值分别为0.612、0.356、0.407、0.411、0.349、0.334,P<0.05)。结论血清Apelin水平变化与BMI、胰岛素抵抗及血脂有关,并可能在PCOS及T2DM的发生发展中起一定的作用。
Objective To determine the level of Apelin in patients with polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM), and to explore its relationship with obesity, sex hormones, metabolic indices and insulin resistance. Methods 24 patients with PCOS, 26 T2DM and 22 normal glucose regulation (NGR) were divided into overweight (OW) and normal weight (normal weight) according to body mass index (BMI) ≥25kg / m2 or <25kg / weight, NW). Fasting serum Apelin, fasting blood glucose (FPG), fasting insulin (FINS) and sex hormones were measured by radioimmunoassay. BMI was calculated and insulin resistance index (HOMA-IR) . Results Serum Apelin levels in PCOS group were significantly higher than those in NGR group [(247.8 ± 47.5) ng / L vs 220.2 ± 42.3 ng / L, P <0.05] 55.2) ng / Lvs. (220.2 ± 42.3) ng / L, P <0.05]. There was no significant difference in serum Apelin levels between PCOS group and T2DM group. In the PCOS, T2DM and NGR groups, Apelin levels were higher in the OW subgroup than in the corresponding NW subgroup. Fasting serum Apelin levels were positively correlated with BMI, FPG, FINS, HOMA-IR, TG and TC (r values were 0.612,0.356,0.407,0.411,0.349,0.334, P <0.05). Conclusion The change of serum Apelin level is related to BMI, insulin resistance and blood lipid, and may play a role in the occurrence and development of PCOS and T2DM.