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背景:新加坡结核病控制中心——一个大规模的国家结核病人诊治中心。 目的:观察抗结核药物诱导性肝炎(DH)的发病率、临床经过、结局及在总体规划条件下与DH有关的危险因素。 设计:对1998年抗结核治疗的成年病人回顾性分析。 结果:1998年治疗的1036例病人中,共发生DH 55例。DH诊断的中位时间为38天。与DH显著有关的因素是基线转氨酶/胆红素异常(OR 2.1,95％CI1.1-4.3,P=0.02),>60岁(OR 1.97,95％CI1.14-3.34,P=0.01)及女性(OR 1.9,95％CI1.07-3.4,P=0.02)。而人种、自报的不同的饮酒量及体重均与叫发生无关。3例致死性肝炎均接受含PZA的方案。48例重新开始治疗者中45例完成治疗。再次建立结核治疗的中位时间为23天。 结论:抗结核药物诱导性肝炎的发生率为5.3％。与DH发生有关的危险因素为>60岁、基线转氨酶/胆红素异常及女性。
Background: The Singapore Tuberculosis Control Center - a large-scale national tuberculosis clinic. Objective: To observe the incidence of anti-TB drug-induced hepatitis (DH), clinical course, outcome and DH-related risk factors under overall planning conditions. Design: A retrospective analysis of adult patients receiving anti-TB therapy in 1998. Results: Among 1036 patients treated in 1998, 55 cases were DH. The median time for DH diagnosis was 38 days. Significantly related to DH were baseline aminotransferase / bilirubin abnormalities (OR 2.1, 95% CI 1.1-4.3, P = 0.02),> 60 years (OR 1.97, 95% CI 1.14-3.34, P = 0.01) And female (OR 1.9, 95% CI 1.07-3.4, P = 0.02). The racial, self-reported different amounts of alcohol and weight are nothing to do with the call. Three cases of lethal hepatitis received PZA-containing regimens. Of the 48 patients who restarted the treatment, 45 completed the treatment. The median time to rebuild TB was 23 days. Conclusion: The incidence of anti-TB drug-induced hepatitis was 5.3%. The risk factors associated with the occurrence of DH were> 60 years, with abnormal baseline aminotransferase / bilirubin and women.