朊病毒是不含核酸的一种蛋白质感染颗粒,感染宿主后可诱导细胞固有的同类朊蛋白(PrPC)构象改变、转化成具有蛋白酶抗性的致病性朊粒蛋白(PrPSc),导致可传播性海绵状脑病的发生.PrPC既作为朊病毒复制和疾病发生的分子基础,又是正常的细胞膜蛋白,作为细胞信号转导的参与者调控多条信号通路.因此,揭示PrPC在各条信号途径中发挥的作用将有助于深入了解PrPC的生理功能,进一步理解疾病发生发展过程,为今后的诊断治疗奠定基础. Prions are nucleic acid-free protein-infected particles that, upon infection, induce cell-specific conformational changes in the prion (PrPC) conformation, resulting in protease-resistant pathogenic prion protein (PrPSc) Spongiform encephalopathiesPrPC both as a molecular basis of prion replication and disease, is a normal cell membrane protein, as a signal transduction cell signaling regulation of multiple signal pathways.Therefore, revealing PrPC in various signal pathways Will help to understand the physiological function of PrPC and further understand the process of disease development and lay the foundation for the future diagnosis and treatment.