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近十年来,美国自患病新生儿中分离出的病原菌,以B族链球菌(下称GBS)最为常见。由于GBS感染可呈早期暴发经过、病死率高至20～50%和患脑膜炎者30%以上可留有神经系统后遗症等,许多作者都致力于研究GBS感染的预防。作者在达拉斯曾给出生后1小时内的新生儿肌注青霉素,观察对GBS带菌率和发病率的影响,并于1980年报告了连续25个月的初步结果[见本刊8(5):217,1981]。当时,青霉素组新生儿GBS带菌率、母一婴带菌率以及青霉素敏感菌(下称敏感菌)感染的发病率均显著降低。但在
In the past ten years, the United States isolated from the sick newborn pathogens to Group B Streptococcus (hereinafter referred to as GBS) the most common. Because GBS infection can be an early outbreak, the mortality rate as high as 20 to 50% and 30% of patients with meningitis may have nervous system sequelae, many authors are committed to studying the prevention of GBS infection. The author gave intramuscular injections of penicillin within 1 hour after birth in Dallas to observe the effects on the incidence and incidence of GBS invaders and reported a preliminary 25-month outcome in 1980 [see Journal 8 (5): 217, 1981]. At that time, the penicillin group neonatal GBS carrier rate, mother and baby carrier rate and penicillin-susceptible (hereinafter referred to as susceptible) incidence of infection were significantly reduced. But in