论文部分内容阅读
目的:比较阻塞性睡眠窒息症(OSA)患者和正常人的图形视网膜电图(PERG)和图形视觉诱发电位(PVEP)。方法:前瞻性横断面研究。研究包含马来西亚医科大学的40例OSA患者和31例正常人。随机选取眼部未发生病变并确诊OSA的患者参与研究。通过记录呼吸暂停低通气指数(AHI)以用于对OSA的严重程度分层。由马来西亚医科大学眼科电生理实验室内训练有素的技术人员对每位患者进行电生理检查(PVEP和PERG)。所得结果记录为中位数。使用IBM Statistics Version 21.0完成数据分析。结果:在OSA患者中,与正常人相比,我们观察到PERG的P50振幅(P<0.001)和PVEP的P100振幅(P<0.001)显著降低。OSA患者PVEP的P100(P=0.003)和N75的峰值时间(P=0.004)均显著升高。然而在OSA患者和正常人之间的PERG的峰值时间检测无显著差异。在不同疾病严重程度的OSA患者中PVEP或PERG也无显着差异。结论:OSA患者PVEP幅度和峰值时间及PERG幅度存在显著异常。这可能反映了OSA中的亚临床视神经功能障碍。需要进一步的研究来确定OSA的严重程度与视神经功能障碍程度之间的关系
OBJECTIVE: To compare the pattern electroporation (PERG) and visual evoked potential (PVEP) in patients with obstructive sleep apnea (OSA) and in normal subjects. Methods: Prospective cross-sectional study. The study included 40 OSA patients and 31 normal subjects from the Malaysian Medical University. Randomly selected patients with ocular lesions and confirmed OSA involved in the study. Apnea-hypopnea index (AHI) was recorded for stratification of the severity of OSA. Electrophysiological examinations (PVEP and PERG) were performed on each patient by trained technicians in the ophthalmic electrophysiology laboratory at Malaysian Medical University. The result is recorded as median. Complete the data analysis using IBM Statistics Version 21.0. RESULTS: In OSA patients, we observed a significant decrease in P50 amplitude (P <0.001) and PVEP P100 amplitude (P <0.001) for PERG as compared to normal individuals. PEP (P = 0.003) and N75 peak time (P = 0.004) in PVEP were significantly increased in patients with OSA. However, there was no significant difference in peak time of PERG between OSA patients and normal subjects. There was no significant difference in PVEP or PERG among OSA patients with different disease severity. Conclusions: There is a significant abnormality of PVEP amplitude, peak time and PERG amplitude in patients with OSA. This may reflect subclinical optic nerve dysfunction in OSA. Further studies are needed to determine the relationship between the severity of OSA and the degree of optic nerve dysfunction