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目的:探讨fms样酪氨酸激酶(Flt-1)基因多态性与低氧训练敏感性的关联性。方法:选取70名中国北方平原地区汉族男子进行4周高住高练低训(HiHiLo),方案为每日在低氧环境(O2浓度为14.5%～14.8%,大约相当于海拔3000米)中休息10h,每周进行3次75%VO2max低氧训练(O2浓度为15.4%,大约相当于海拔2500米),其余时间在常氧下训练。测试其HiHiLo前后的VO2max及训练期间的血象指标。用PCR-RFLP法分析Flt-1基因SNP/A193019G多态性。结果:(1)4周HiHiLo后,AA基因型VO2max增加幅度高于AG基因型57.54%,但无显著性差异。(2)在HiHiLo期间(除第23天外),AA基因型Hb的变化幅度始终高于AG基因型,但无显著性差异。结果提示,与AG基因型者相比,AA基因型者可能有对低氧训练更敏感的趋势。
Objective: To investigate the association between fms-like tyrosine kinase (Flt-1) gene polymorphism and hypoxia training sensitivity. Methods: Forty Han Chinese men in the northern plains of China were enrolled in this study. HiHiLo training was performed for 4 weeks in a hypoxic environment (O2 concentration of 14.5% ~ 14.8%, equivalent to an altitude of 3000 meters) After a 10-hour rest, 75% VO2max hypoxia training was performed three times a week (O2 concentration 15.4%, equivalent to an altitude of 2,500 meters) and trained under normoxia for the rest of the day. VO2max before and after the test HiHiLo and blood indicators during training. Flt-1 gene SNP / A193019G polymorphism was analyzed by PCR-RFLP. Results: (1) After 4 weeks of HiHiLo, AA genotype VO2max increased more than 57.54% of AG genotype, but no significant difference. (2) During the HiHiLo period (except day 23), the variation of AA genotype Hb was always higher than that of AG genotype, but there was no significant difference. The results suggest that AA genotypes may be more susceptible to hypoxic training than AG genotypes.