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目的评价丹参酮ⅡA磺酸钠和低分子肝素钙在进展型脑梗死治疗中的作用,提高脑梗死患者治愈率,改善其生存质量。方法将76例进展型脑梗死患者随机分为两组,每组38例。治疗组予以低分子肝素钙5 000IU皮下注射,每日2次,共7d联合丹参酮ⅡA磺酸钠60mg加入5%葡萄糖250ml中静脉滴注,每日一次,连用14d;对照组予以常规治疗。2周后根据神经功能缺损评分和实验室指标判定疗效。结果两组治疗前后比较,临床治疗有效率差异有统计学意义(P<0.01)。结论丹参酮ⅡA磺酸钠联合低分子肝素钙治疗进展型脑梗死为安全有效的治疗方案,丹参酮ⅡA磺酸钠可降低全血黏度,改善预后。
Objective To evaluate the effect of sodium tanshinone Ⅱ A sulfonate and low molecular weight heparin calcium in the treatment of advanced cerebral infarction and improve the cure rate and quality of life in patients with cerebral infarction. Methods 76 patients with progressive cerebral infarction were randomly divided into two groups, 38 cases in each group. The treatment group was given low molecular weight heparin 5 000IU subcutaneous injection twice a day for 7 days combined with sodium tanshinone Ⅱ A sulfonate 60mg 5% glucose 250ml intravenous infusion once daily for 14 days; the control group was routinely treated. After 2 weeks according to neurological deficit score and laboratory indicators to determine the efficacy. Results Before and after treatment, the effective rate of clinical treatment was statistically significant (P <0.01). Conclusion Tanshinone Ⅱ A sulfonate combined with low molecular weight heparin calcium is a safe and effective treatment for advanced cerebral infarction. Sodium tanshinone Ⅱ A sulfonate can reduce whole blood viscosity and improve prognosis.