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目的了解吸毒人群戊型肝炎病毒(HEV)感染情况,分析此人群高危行为方式与HEV感染之间的联系,为预防和控制戊型肝炎提供依据。方法采用横断面研究,从戒毒所和美沙酮门诊选择379名吸毒者,调查其吸毒行为方式、性行为特点,用ELISA法检测HEV-IgG抗体,分析吸毒人群戊型肝炎感染的影响因素。结果调查人群静脉注射吸毒的比例为52.8%,吸毒人群戊肝感染率为8.4%,40岁以上年龄组人群HEV感染率为16.3%,高于其他年龄组感染率(χ2=10.580,P=0.005);吸食海洛因的人群HEV感染率为12.0%,高于吸食冰毒人群的3.4%和吸食其他毒品人群的6.3%,差异有统计学意义(χ2=8.542,P=0.014);静脉吸毒人群的感染率为12.5%,高于非静脉吸毒人群的3.9%,差异有统计学意义(χ2=9.015,P=0.003)。结论静脉注射吸毒和年龄因素可能是吸毒人群HEV高感染的重要因素。
Objective To understand the infection status of hepatitis E virus (HEV) in drug addicts and to analyze the association between high risk behaviors and HEV infection in this population and to provide basis for the prevention and control of hepatitis E. Methods A cross-sectional study was conducted to select 379 drug addicts from drug addicts and methadone clinics to investigate their drug abuse behaviors and behavior characteristics. HEV-IgG antibodies were detected by ELISA and the influencing factors of hepatitis E infection were analyzed. Results The prevalence of intravenous drug use in the population was 52.8%, that of the drug users was 8.4%, and that of the population over the age of 40 was 16.3%, higher than those in other age groups (χ2 = 10.580, P = 0.005 ). The infection rate of HEV among heroin abusers was 12.0%, higher than 3.4% of those taking methamphetamine and 6.3% of those taking other drugs.The difference was statistically significant (χ2 = 8.542, P = 0.014). Infection of intravenous drug users The rate was 12.5%, higher than that of non-intravenous drug users (3.9%), the difference was statistically significant (χ2 = 9.015, P = 0.003). Conclusion Intravenous drug abuse and age factors may be an important factor of HEV infection in drug addicts.