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目的探讨新型抑癌基因Runx3蛋白表达与胃腺癌发生、发展、临床病理特征及患者预后之间的关系。方法用免疫组织化学SP法,检测63例胃腺癌组织、19例胃黏膜不典型增生组织及10例因胃良性病变行部分切除的正常胃黏膜组织中Runx3蛋白的表达。结果(1)Runx3蛋白在胃癌中阳性表达率为39.7%,明显低于胃黏膜不典型增生组织68.4%及正常胃黏膜组织90%,差异具有统计学意义(P<0.05)。(2)Runx3蛋白阳性表达与胃癌组织病理分级、浸润深度、淋巴结转移有关,而与患者的年龄、性别、大小及临床分期无关。(3)Runx3蛋白表达阳性者的生存率高于表达阴性者的生存率(P<0.05)。Runx3蛋白阳性者,术后生存时间长。结论Runx3蛋白对胃癌的发生发展起重要作用,是评估胃癌患者预后的一项重要指标。
Objective To investigate the relationship between Runx3 protein expression and the occurrence, development, clinicopathological features and prognosis of gastric adenocarcinoma. Methods Immunohistochemical SP method was used to detect the expression of Runx3 protein in 63 cases of gastric adenocarcinoma, 19 cases of gastric mucosa atypical hyperplasia and 10 cases of normal gastric mucosa resected due to gastric benign lesions. Results (1) The positive rate of Runx3 protein in gastric cancer was 39.7%, which was significantly lower than 68.4% in gastric mucosa atypical hyperplasia and 90% in normal gastric mucosa, the difference was statistically significant (P <0.05). (2) The positive expression of Runx3 protein was correlated with histological grade, depth of invasion and lymph node metastasis, but not with patient’s age, sex, size and clinical stage. (3) The survival rate of Runx3 positive patients was higher than that of negative ones (P <0.05). Runx3 protein positive, long survival time after surgery. Conclusion Runx3 protein plays an important role in the occurrence and development of gastric cancer and is an important index for evaluating the prognosis of gastric cancer patients.