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[目的]探讨家兔低温敏感性与振动性神经功能损伤之间的相关性。[方法]首先对家兔进行低温试验,按照试验前后测定指标的变化情况,确定内皮素(ET)、感觉神经传导速率(SCV)为低温敏感性指标。根据低温试验前后ET、SCV的变化情况分别进行分组。前后变化<25%者为低度敏感组;变化25%～50%者为中度敏感组;变化>50%者为高度敏感组。分组后,低、中、高度敏感组家兔分别为15、13、12只。然后,进行接振试验,测定各组家兔接振后SCV、感觉神经动作电位波幅、感觉神经动作电位潜伏时、运动神经传导速率(MCV)、运动神经远端波幅、运动神经远端潜伏时的变化。[结果]与接振试验前比较,接振后SCV、MCV、感觉神经动作电位波幅、运动神经远端波幅降低,感觉神经动作电位潜伏时、运动神经远端潜伏时延长(P<0.05)。SCV、MCV、感觉神经动作电位波幅、运动神经远端波幅在低、中、高敏感组依次降低;感觉神经动作电位潜伏时、运动神经远端潜伏时依次延长,差异有统计学意义(P<0.01)。将低温试验后的血浆ET浓度、SCV测定值与接振后的振动性神经功能损伤指标SCV(r=-0.872,r=0.847)、感觉神经动作电位波幅(r=-0.750,r=0.925)、感觉神经动作电位潜伏时(r=0.850,r=-0.799)、MCV(r=-0.705,r=0.843)、运动神经远端波幅(r=-0.943,r=0.940)、运动神经远端潜伏时(r=0.941,r=-0.931)的测定值进行简单相关分析,结果显示上述相关系数r值均具有统计学意义(P<0.01)。[结论]低温敏感性与振动性神经功能损伤具有相关性;振动性神经功能损伤在低、中、高3个敏感组中依次加重;但两者相关性的原因尚待研究。
[Objective] To explore the correlation between hypothermia sensitivity and vibrational nerve function impairment in rabbits. [Method] At first, the rabbits were subjected to hypothermia test, and the endothelin (ET) and sensory nerve conduction velocity (SCV) were determined as low temperature sensitivity index according to the changes of the measured indexes before and after the test. According to the changes of ET and SCV before and after the low temperature test, the patients were divided into groups. Before and after the change of <25% for the low sensitivity group; changes of 25% to 50% were moderately sensitive group; changes> 50% were highly sensitive group. After grouping, the rabbits in low, medium and high sensitive groups were 15, 13 and 12 respectively. Then, vibration test was performed to measure the amplitude of SCV, sensory nerve action potential amplitude and sensory nerve action potential latency in each group after rabbits were revived. The motor nerve conduction velocity (MCV), distal motor nerve amplitude, latency of distal motor nerve The change. [Result] The amplitude of SCV, MCV, sensory nerve action potential amplitude and the amplitude of distal motor nerve were decreased after sensitization and the latency of motor nerve was prolonged (P <0.05). SCV and MCV, the amplitude of sensory nerve action potential and the distal amplitude of motor nerve decreased in the low, middle and high sensitivity groups, while the sensory nerve action potentials were latent, the motor nerve was prolonged in the distal latency, the difference was statistically significant (P < 0.01). The plasma ET concentration, SCV and SCV (r = -0.872, r = 0.847) and sensory nerve activity potential amplitude (r = -0.750, r = 0.925) (R = -0.705, r = 0.843), distal motor nerve amplitude (r = -0.943, r = 0.940), sensory nerve potential latency (r = 0.850, r = -0.799) Latent (r = 0.941, r = -0.931) measured values were simple correlation analysis, the results showed that the correlation coefficient r values were statistically significant (P <0.01). [Conclusion] There is a correlation between hypothermia sensitivity and vibrational neurological impairment. The vibrational neurological impairment increased in three sensitive groups at low, middle and high levels successively. However, the reason of the correlation between the two is still to be studied.