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目的观察氯吡格雷片治疗不稳定型心绞痛的临床疗效。方法将68例符合纳入标准的不稳定型心绞痛患者根据就诊先后顺序,用随机数字表分为两组。对照组30例,给予消心痛片10 mg/次,3次/d,口服;肠溶阿司匹林片100 mg/d,口服;心痛定片10 mg/次,3次/d,口服。治疗组38例,在对照组治疗基础上加用氯吡格雷片75 mg/次,1次/d,口服。两组患者均给予针对危险因素的降糖、降压、降脂治疗,并给予低盐、低脂饮食,注意休息。14 d为1个疗程,2个疗程结束后统计疗效。结果①两组疗效比较:对照组平均秩次为28.48,治疗组平均秩次为39.25,Z检验统计量为Z=-2.422,P=0.015(双侧),治疗组明显优于对照组。②治疗组总有效率为92.11%,对照组总有效率为73.33%,两组比较差异有统计学意义(χ2=4.357,ν=1,P=0.037),治疗组优于对照组。③所有患者均按要求完成了治疗研究,显示了治疗药物的良好依从性。结论氯吡格雷片治疗不稳定型心绞痛有较好的临床疗效,且毒副作用小,依从性好,值得进一步研究推广。
Objective To observe the clinical efficacy of clopidogrel in the treatment of unstable angina pectoris. Methods Sixty-eight patients with unstable angina who met the inclusion criteria were divided into two groups according to the order of their visits. The control group was given 30 tablets of XHXP (10 mg / time, 3 times / d) orally. The aspirin tablets were given orally at 100 mg / d. In the treatment group, 38 cases were treated with clopidogrel 75 mg once daily for oral administration. Two groups of patients were given for the risk factors of hypoglycemic, antihypertensive, lipid-lowering treatment, and given low-salt, low-fat diet, pay attention to rest. 14 d for a course of treatment, after two courses of statistical effect. Results ① Comparison of the two groups: the average rank of the control group was 28.48, the average rank of the treatment group was 39.25, Z test statistic was Z = -2.422, P = 0.015 (both sides), the treatment group was significantly better than the control group. ② The total effective rate was 92.11% in the treatment group and 73.33% in the control group. The difference between the two groups was statistically significant (χ2 = 4.357, ν = 1, P = 0.037). The treatment group was superior to the control group. ③ All patients completed the treatment study as required, demonstrating good adherence to the treatment medication. Conclusion Clopidogrel tablets for the treatment of unstable angina pectoris have better clinical curative effect with less toxic and side effects and good compliance, which deserves further study and promotion.