论文部分内容阅读
目的探讨血清25-羟维生素D3[25(OH)D3]水平与哮喘患儿炎症反应及肺功能的关系。方法选择2015年3月-2016年3月该院接受治疗的哮喘患儿500例作为观察组,另取同期体检的健康儿童100例作为对照组。分别对比两组儿童的血清细胞因子、肺功能、血清25(OH)D3、血钙、血磷和碱性磷酸酶水平,并应用Pearson相关性分析分析相关性。结果观察组儿童血清25(OH)D3水平显著低于对照组,差异有统计学意义(t=2.786,P<0.05),两组儿童血钙、血磷和碱性磷酸酶水平比较差异无统计学意义(t=0.483、0.436、0.728,均P>0.05)。观察组儿童血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、γ-干扰素(INF-γ)水平均显著高于对照组,差异有统计学意义(t=2.887、3.017、2.803,均P<0.05)。观察组儿童第一秒用力呼气容积(FEV1)、呼气流量峰值(PEF)、一秒用力呼气量占用力肺活量比值(FEV1/FVC)水平均显著低于对照组,差异有统计学意义(t=2.726、2.775、3.009,均P<0.05)。经Pearson相关性分析可得,血清25(OH)D3水平与TNF-α、IL-6、INF-γ呈负相关(r值分别为-0.694、-0.752、-0.542,均P<0.05),与FEV1、PEF及FEV1/FVC呈正相关(r值分别为0.573、0.719、0.543,均P<0.05)。结论哮喘患儿血清25(OH)D3水平下降,与患儿炎症反应及肺功能密切相关,临床治疗中可通过提高患儿血清25(OH)D3水平,以改善炎症反应程度及肺功能。
Objective To investigate the relationship between serum 25-hydroxyvitamin D3 (25 (OH) D3] and inflammatory reaction and pulmonary function in asthmatic children. Methods From March 2015 to March 2016, 500 children with asthma treated in this hospital were selected as the observation group and 100 healthy children taking the same period as the control group. Serum cytokines, lung function, serum 25 (OH) D3, serum calcium, phosphorus and alkaline phosphatase levels were compared between the two groups. Pearson correlation analysis was used to analyze the correlation. Results The level of serum 25 (OH) D3 in observation group was significantly lower than that in control group (t = 2.786, P <0.05). There was no statistical difference in serum calcium, phosphorus and alkaline phosphatase Significance (t = 0.483,0.436,0.728, all P> 0.05). The level of serum tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interferon-γ in the observation group were significantly higher than those in the control group (t = 2.887 , 3.017, 2.803, all P <0.05). FEV1, PEF and FEV1 / FVC in observation group were significantly lower than those in control group, the difference was statistically significant (t = 2.726, 2.775, 3.009, all P <0.05). Pearson correlation analysis showed that serum 25 (OH) D3 level was negatively correlated with TNF-α, IL-6 and INF-γ (r = -0.694, -0.752, -0.542, all P < And FEV1, PEF and FEV1 / FVC were positively correlated (r values were 0.573,0.719,0.543, all P <0.05). Conclusion The serum level of 25 (OH) D3 in children with asthma is decreased, which is closely related to the inflammatory reaction and pulmonary function in children. The serum level of 25 (OH) D3 can be improved in children with asthma to improve the degree of inflammatory reaction and lung function.