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目的:探讨高尔基体蛋白73(GP73)和甲胎蛋白(AFP)在监测肝细胞肝癌(HCC)肝切除术后疗效及复发中的作用。方法:收集确诊为肝细胞肝癌并行肝切除术的患者93例,术后随访,监测患者血清GP73和AFP水平。结果:GP73和AFP血清水平与肿瘤大小、数目、有无包膜形成及包膜浸润、有无血管浸润、肝内转移以及肿瘤分化程度相关。随着GP73和AFP浓度升高,GP73和AFP诊断HCC的敏感性降低,而特异性升高。术前和术后GP73和AFP均阳性的患者6个月内肿瘤的复发率明显升高。结论:GP73和AFP是良好的监测HCC术后疗效及肿瘤复发的血清标记物。
Objective: To investigate the effect of GP73 and AFP on the curative effect and recurrence of hepatocellular carcinoma (HCC) after hepatectomy. Methods: Ninety-three patients with concurrent hepatectomy diagnosed as hepatocellular carcinoma were collected. The patients were followed up and the serum GP73 and AFP levels were monitored. Results: The serum levels of GP73 and AFP correlated with tumor size, number, presence or absence of capsule formation and infiltrating infiltration, with or without vascular invasion, intrahepatic metastasis and tumor differentiation. With the increase of GP73 and AFP concentrations, the sensitivity and specificity of GP73 and AFP in diagnosing HCC decreased. The recurrence rate of tumor in 6 months was significantly higher in patients with positive GP73 and AFP both before and after operation. Conclusion: GP73 and AFP are good serum markers for monitoring the efficacy and recurrence of HCC.